Механическая устойчивость опухолей и повреждающие побочные эффекты лечения зачастую сильно снижают успешность противораковой терапии. Благодаря аномальной структуре коллагеновых волокон и внеклеточного матрикса раковые опухоли отличаются повышенной ригидностью (жесткостью). Ригидность не только указывает на злокачественную природу опухоли, но также способствует ее росту и формированию метастаз. Кроме того, она является физическим барьером, ограничивающим проникновение в опухоль лекарственных препаратов. Методы лечения, преодолевающие этот барьер, небезопасны, так как одновременно неизбежно повреждают здоровые органы и ткани.

По итогам экспериментов с опухолями у мышей французские ученые предложили новый метод борьбы с раком. После введения в опухоль углеродных нанотрубок, их температуру повышали с помощью ближнего к инфракрасному лазерного излучения. Во время эксперимента опухоли подвергалась трехминутному локальному нагреву — наногипертермии. Процедуру повторяли дважды через день. Жесткость опухоли оценивали с помощью ультразвукового сканирования. В результате эксперимента опухоли сначала, наоборот, становились жестче, но затем, на протяжении десятидневного периода, постепенно размягчались. Опыты показали, что наногипертермия модифицировала структуру волокон коллагена внутри опухоли и, как следствие, приводила к снижению ее ригидности и объема. Метод заявлен как перспективный в качестве сопровождающей химиотерапию процедуры.

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