Мутации генов BRCA1 и BRCA2 обычно считают причиной развития рака молочной железы у женщин. Однако и для мужчин они представляют серьезную опасность.

Каждый раз, когда Пит Пассанісі пристегивал ремень безопасности в машине, он чувствовал дискомфорт. Там, где ремень слева касался его груди, возникала боль.

Сначала он думал, что потянул мышцу. Или что это — изжога. Но в конце концов родные убедили его тщательно ощупать грудь, и он обнаружил несколько шишек, мелких и жестких, как леденцы.

В декабре 2011 года Пассанісі, которому тогда было 66, сделал биопсию в местной больнице в Лейк-Сент-Луис (штат Миссури, США) и на следующий день после Рождества узнал, что шишки — это онкология, вторая стадия рака молочной железы.

Ему провели мастэктомию (удаление грудной железы), а чуть позже — лімфаденектомія (удаление лимфоузлов).

«Ремень безопасности спас ему жизнь», — говорит Энни, дочь Пассанісі.

Через несколько месяцев после операции отца 27-летняя женщина узнала, что и сама является носителем того же гена, что мутирует, который вызвал развитие рака у Пита Пассанісі.

Сегодня Энни проходит регулярные обследования, в частности МРТ и маммографию. «Если ген проявит себя, она узнает об этом на ранней стадии», — говорит Пит.

Мутации гена BRCA2 значительно повышают риск развития рака молочной железы и яичников.

Гены BRCA1 и BRCA2 — гены-супрессоры опухолей, они отвечают за починку поврежденных генов. Когда они перестают это делать правильно, в ДНК возникает все больше ошибок, что в конечном итоге ведет к раку.

Диагноз Пита Пассанісі помог его дочери Энни узнать, что она также является носителем гена BRCA2

Риск мутаций генов BRCA1 и 2 одинаков для женщин и мужчин, но мужчины в 10 раз реже проходят такое обследование.

Одна из причин — общее ошибочное представление о том, что такие гены равнозначны рака молочной железы (а многие мужчины уверены, что в них нет ткани молочной железы).

Конечно, у мужчин меньше таких тканей, чем у женщин, и следовательно, ниже риск развития рака молочной железы, даже если в них есть ген BRCA2.

Дело, однако, в том, что с мутациями этого гена связаны и другие опасности.

Во-первых, они представляют риск для детей мужчины, у которого есть такой поврежденный ген.

Вероятность того, что мужчина передаст мутировавший ген своим детям, равна 50%, как и в случае с женщинами.

Если дочери такого человека унаследуют эту мутацию, то до 70 лет шансы на развитие рака молочной железы у них — от 50 до 85%.

«Если бы большее число мужчин согласились пройти проверку, они помогли бы женщинам в своих семьях принять меры и начать регулярные обследования», — объясняет Джули Ране Нангіа, директор клиники предупреждения рака молочной железы в Бейлорському медицинском колледже в Хьюстоне (штат Техас).

Но дело не только в том, как мутация гена влияет на организм женщин. Согласно одним из последних исследований, у тех мужчин, которые имеют ген BRCA2, вдвое более высокие шансы заболеть раком простаты, чем у тех, кто не имеет такого гена.

Гены BRCA1 и BRCA2 традиционно связывают с женским раком молочной железы. Но их можно найти и у мужчин

12% мужчин с метастатическим раком предстательной железы — носители мутаций гена BRCA. И этот процент выше, чем у женщин с раком молочной железы, у которых также есть этот ген.

Рак простаты у носителей BRCA2 гораздо чаще имеет более агрессивный характер.

«Я считаю, что мы должны обследовать людей с раком простаты на мутации генов, чтобы избежать ситуации, когда хирург предлагает: «давайте подождем и посмотрим», — отмечает Стивен Нерод, онколог, руководитель отдела исследования рака молочной железы в Университете Торонто (Канада).

«Консервативный подход к лечению рака предстательной железы у мужчин с мутацией гена BRCA противопоказан», — объясняет специалист.

В среднем только 39% мужчин с мутацией гена BRCA2 могут прожить более пяти лет после диагноза «рак простаты». Хотя это, конечно, очень зависит от уровня медицины в стране, где вы живете.

Впрочем, для мужчин с раком простаты и поврежденным BRCA2 есть гораздо более эффективные виды лечения, чем для остальных пациентов с раком предстательной железы. И если начать лечение рано, то прогноз — оптимистический.

Чем шире будут обследования мужчин с целью выявить мутации гена, то легче диагностировать рак на ранних стадиях развития.

Рус Ілз, генетик, изучающий злокачественные опухоли в Институте исследования рака в Лондоне, недавно руководивший исследованием рисков развития рака простаты у пациентов с геном BRCA2.

Он призывает всех мужчин с таким геном после 40 лет регулярно сдавать анализ крови (тест на ПСА), чтобы держать под контролем состояние простаты.

Обследование на наличие мутаций BRCA2 позволяет понять степень риска и как можно раньше выявить заболевание

В Великобритании, например, все еще официально рекомендуют пройти генетический тест на мутации гена BRCA только членам семей с историей заболевания раком простаты, молочной железы или яичников.

Никаких превентивных мер не предусмотрено.

Но такие меры могли бы изменить ложное представление о том, что мутации гена BRCA повышают риск только для женщин, отмечает Джули Ране Нанг.

Терапевты не рекомендуют то, в чем сами не очень разбираются.

Однако генетические исследования становятся доступнее и дешевле, и есть надежда, что все больше людей будут проходить обследование.

Сегодня немало кампаний привлекают внимание к проблеме рака груди у мужчин

Такие генетические тесты в коммерческих клиниках можно сделать даже без направления врача. Их стоимость — примерно 250 долларов США.

Конечно, у таких тестов есть и свои минусы. Их результаты должен проанализировать генетик, в противном случае их могут неправильно интерпретировать.

Вы можете быть носителем гена, который связывают с тем или иным заболеванием, но это не означает, что это заболевание у вас обязательно будет.

Джули Ране Нангіа мечтает о том дне, когда генетические тесты с разъяснением результатов включат бесплатных услуг системы здравоохранения — независимо от того, или есть семейная история заболевания.

Тогда у таких людей, как дочь Пита Пассанісі, будет больше шансов оставаться здоровыми в течение жизни.

«С одной стороны, я чувствую вину и угрызения совести за то, что передал Энни этот ген, — делится Пот. — Но с другой стороны, я рад, что ей стало известно о нем».

«Это дает возможность пристально следить за состоянием здоровья и заранее найти нужных людей, которые помогут», — добавляет мужчина.

Прочитать оригинал этой статьи на английском языке можно на сайте BBC Future.

Хотите поделиться с нами своими жизненными историями? Напишите о себе на адрес questions.ukrainian@bbc.co.uk и наши журналисты с вами свяжутся.

Хотите получать главное в мессенджер? Подписывайтесь на наш Telegram или Viber!

Также на эту тему

  • Общество
  • Рак
  • Здоровья

695 КОММЕНТАРИИ

  1. Interesting blog! Is your theme custom made or did you download it from somewhere?
    A theme like yours with a few simple tweeks would really make my blog jump out.
    Please let me know where you got your design. Thank you

  2. This design is spectacular! You certainly know how
    to keep a reader entertained. Between your wit and your videos, I
    was almost moved to start my own blog (well, almost…HaHa!) Fantastic job.
    I really loved what you had to say, and more than that, how you presented it.

    Too cool!

    my web blog … mpc-install.com

  3. Simply desire to say your article is as surprising.
    The clearness on your post is simply cool and i can suppose you are knowledgeable in this subject.
    Well together with your permission let me to snatch your feed to keep up to date with approaching post.
    Thanks a million and please carry on the gratifying work.

    Also visit my blog … https://kebe.top

  4. I wanted to thank you a lot more for the amazing site you
    have made here. It really is full of ideas for
    those who are seriously interested in this subject,
    especially this very post. You really are all so sweet
    in addition to thoughtful of others and reading your blog posts is a superb delight to me.
    And what generous reward! Dan and I will certainly have enjoyment making use of your suggestions in what we must do in the near future.
    Our collection of ideas is a kilometer long and simply put tips might be put to great use.

    my site :: https://www.memorytoday.com

  5. I just now wanted to thank you once again for that amazing
    site you have developed here. It can be full of useful tips for those who are truly interested in this
    kind of subject, in particular this very post. You really
    are all absolutely sweet and thoughtful of others plus reading your blog posts is a fantastic delight if you ask me.
    And what generous gift! Ben and I usually have excitement making use of your ideas
    in what we must do in a few days. Our collection of ideas is a kilometer long which
    means your tips will certainly be put to fine use.

    Feel free to visit my web page: http://163.30.42.16/~health2017/userinfo.php?uid=4314665

  6. My spouse and I absolutely love your blog and find a lot of your post’s to be just what I’m looking for.
    Does one offer guest writers to write content for you?
    I wouldn’t mind creating a post or elaborating on some of the subjects you write regarding here.
    Again, awesome website!

    Here is my blog post :: kebe.top

  7. I must express some appreciation to you for bailing me
    out of this situation. Right after researching throughout the internet
    and seeing strategies which are not beneficial, I figured my life was gone.
    Being alive without the approaches to the difficulties you have fixed
    all through your entire site is a critical case,
    as well as those which may have adversely damaged my entire career if I hadn’t encountered your web page.
    The expertise and kindness in touching all the pieces
    was valuable. I’m not sure what I would’ve done if I hadn’t encountered such a point like this.
    I am able to now relish my future. Thanks a lot so much for this expert and result oriented help.

    I won’t think twice to endorse the blog to anybody who ought to have support on this problem.

    My website https://mpc-install.com/punbb-1.4.6/viewtopic.php?id=245651

  8. Do you mind if I quote a few of your posts as long as I provide credit and sources back to your weblog?

    My blog site is in the very same niche as yours
    and my users would certainly benefit from some of the information you
    present here. Please let me know if this alright with you. Appreciate it!

    my page: clubriders.men

  9. I was suggested this blog by means of my cousin. I am
    not certain whether this publish is written by means of him
    as no one else realize such designated about my problem.

    You’re wonderful! Thank you!

    Also visit my web site :: Graig

  10. I had been honored to receive a call coming from a friend when he found the
    important recommendations shared on the site. Studying your blog posting is a real great experience.
    Thanks again for taking into account readers like me, and I want for
    you the best of success being a professional in this realm.

    My web-site: bbs.shishiedu.com

  11. Hello would you mind sharing which blog platform you’re
    using? I’m going to start my own blog soon but I’m having a hard time
    making a decision between BlogEngine/Wordpress/B2evolution and Drupal.
    The reason I ask is because your design seems different then most blogs and I’m looking for something completely unique.
    P.S Apologies for being off-topic but I had to ask!

    my web blog 163.30.42.16

  12. Wonderful blog! Do you have any tips for aspiring writers?
    I’m planning to start my own website soon but I’m a little
    lost on everything. Would you recommend starting with a free platform like
    Wordpress or go for a paid option? There are so many choices out there that I’m completely overwhelmed ..
    Any suggestions? Bless you!

    my website :: Sanford

  13. I as well as my friends have already been reading through the excellent helpful hints
    from your site while unexpectedly developed a horrible suspicion I
    had not thanked you for those tips. These
    ladies appeared to be as a result stimulated to learn them and now have clearly been loving these things.
    Many thanks for being indeed kind as well as for making a decision on this form of really good
    information millions of individuals are really desperate to understand about.
    My personal honest regret for not expressing gratitude to you sooner.

    Look into my site — mpc-install.com

  14. First of all I want to say wonderful blog!
    I had a quick question which I’d like to ask if you do
    not mind. I was curious to know how you center yourself and clear your head prior
    to writing. I’ve had difficulty clearing my mind in getting my ideas out.
    I truly do enjoy writing but it just seems like the
    first 10 to 15 minutes tend to be lost simply just trying to figure out how to begin. Any ideas or hints?
    Many thanks!

    Here is my site; http://www.consulenzaleonardo.com

  15. Greetings from Idaho! I’m bored to death at work
    so I decided to check out your blog on my iphone during lunch break.
    I really like the info you present here and can’t wait to take a look when I get home.

    I’m shocked at how quick your blog loaded on my mobile ..
    I’m not even using WIFI, just 3G .. Anyways, very good site!

    Review my web page :: https://mpc-install.com/punbb-1.4.6/viewtopic.php?id=257151

  16. With havin so much content do you ever run into any problems of plagorism or copyright infringement?
    My website has a lot of exclusive content I’ve either created myself or outsourced but it looks like a lot of it is popping it up
    all over the internet without my authorization. Do you
    know any techniques to help protect against content from being stolen? I’d genuinely appreciate it.

    Have a look at my blog post … clubriders.men

  17. Hello There. I found your blog using msn. This is an extremely well written article.

    I’ll be sure to bookmark it and return to read more of your
    useful info. Thanks for the post. I’ll certainly comeback.

  18. I simply had to thank you so much again. I’m not certain the things that I would have done without the actual
    points shared by you concerning that theme. It had been a very daunting matter for me personally, however , understanding this expert mode you dealt with it forced me to jump over delight.
    I am grateful for the work as well as trust you are aware
    of a great job you’re accomplishing teaching the rest all through your webblog.
    I am sure you have never met all of us.

    Feel free to surf to my blog mpc-install.com

  19. I create a leave a response whenever I especially enjoy a article on a
    site or if I have something to valuable to contribute to the conversation. Usually it’s a result of the passion communicated in the post
    I read. And on this article Почему гены рака
    молочной железы так же опасны для мужчин.
    I was excited enough to post a commenta response 😛 I actually do have some
    questions for you if it’s okay. Is it only me or
    do some of these comments come across as if they
    are coming from brain dead visitors? 😛 And, if you are posting on additional sites, I’d like to follow everything
    new you have to post. Could you list every one of all your
    communal sites like your Facebook page, twitter feed,
    or linkedin profile?

    Also visit my web site :: http://www.mhes.tyc.edu.tw

  20. Wonderful goods from you, man. I’ve take into
    accout your stuff previous to and you are simply too excellent.
    I really like what you’ve bought here, certainly like what you are stating and the
    best way wherein you are saying it. You are
    making it entertaining and you still take care of to stay
    it smart. I can’t wait to read far more from you. This is actually a terrific site.

    Take a look at my web-site … mpc-install.com

  21. It’s a shame you don’t have a donate button! I’d without a doubt donate to
    this brilliant blog! I suppose for now i’ll settle
    for book-marking and adding your RSS feed to my Google account.
    I look forward to new updates and will talk about this site with my Facebook group.
    Talk soon!

    My site … 163.30.42.16

  22. Hello would you mind stating which blog platform you’re using?
    I’m looking to start my own blog soon but I’m having a tough
    time selecting between BlogEngine/Wordpress/B2evolution and Drupal.

    The reason I ask is because your design seems different then most blogs and I’m looking for
    something completely unique. P.S Apologies for getting off-topic but I
    had to ask!

    My website; https://mpc-install.com/punbb-1.4.6/viewtopic.php?id=255126

  23. Hey I am so glad I found your website, I really found you by accident,
    while I was looking on Askjeeve for something else, Nonetheless I am here now and
    would just like to say cheers for a incredible post and a all
    round entertaining blog (I also love the theme/design), I don’t have
    time to go through it all at the moment but I have bookmarked it and also included
    your RSS feeds, so when I have time I will be back to read
    a lot more, Please do keep up the great job.

    Feel free to surf to my page: http://www.atomy123.com/forum.php?mod=viewthread&tid=268809

  24. I know this if off topic but I’m looking into starting my own weblog
    and was curious what all is required to get set up? I’m
    assuming having a blog like yours would cost a pretty penny?

    I’m not very internet smart so I’m not 100% sure.
    Any tips or advice would be greatly appreciated.
    Appreciate it

    Also visit my web-site: clubriders.men

  25. Hi would you mind stating which blog platform you’re using?
    I’m going to start my own blog soon but I’m having a difficult time selecting between BlogEngine/Wordpress/B2evolution and Drupal.
    The reason I ask is because your design seems different then most blogs and I’m looking for something unique.
    P.S Sorry for being off-topic but I had to ask!

    Stop by my web page: haojiafu.net

  26. Thank you, I have just been searching for information approximately this subject for a long
    time and yours is the greatest I have came
    upon till now. However, what in regards to the bottom line?
    Are you positive concerning the supply?

    My blog post … Yanira

  27. I have been exploring for a little bit for any high-quality articles or blog posts on this kind of area .
    Exploring in Yahoo I finally stumbled upon this web site.
    Studying this information So i am happy to show that I’ve an incredibly just right
    uncanny feeling I found out exactly what I needed.
    I such a lot surely will make certain to do not forget this website and give it a glance on a constant
    basis.

    Also visit my webpage; https://mpc-install.com/punbb-1.4.6/viewtopic.php?id=254989

  28. My spouse and I absolutely love your blog and find many of your post’s to be just what I’m looking for.
    Does one offer guest writers to write content for
    yourself? I wouldn’t mind creating a post or elaborating
    on most of the subjects you write regarding here. Again,
    awesome site!

    Also visit my web-site … http://www.social-work.ipt.pw/out/public-profile-freidanakam-quick-register-info-free-classifieds-ads/

  29. I was just looking for this info for a while. After six hours of continuous
    Googleing, finally I got it in your website. I wonder what’s the lack of
    Google strategy that do not rank this kind of informative sites in top of the list.
    Usually the top web sites are full of garbage.

    My homepage: qijiang520.com

  30. Its such as you read my thoughts! You appear to
    grasp so much about this, like you wrote the guide in it or something.

    I feel that you can do with some percent to drive the message
    house a bit, but other than that, that is wonderful blog.

    A fantastic read. I will definitely be back.

    Take a look at my web site; mpc-install.com

  31. Hi there great blog! Does running a blog such as this take a massive amount work?
    I’ve absolutely no knowledge of computer programming however I was hoping to start my own blog soon. Anyways, should you have any
    ideas or techniques for new blog owners please share. I know this is off topic however I just wanted to ask.

    Thanks!

    my site … haojiafu.net

  32. I drop a comment when I appreciate a post on a
    site or I have something to valuable to contribute to the
    discussion. Usually it is a result of the passion communicated in the article I looked at.
    And on this post Почему гены рака молочной железы так же опасны для
    мужчин. I was excited enough to post a thought ;
    ) I do have 2 questions for you if you tend not to mind.
    Could it be just me or do a few of the remarks look as if they are left
    by brain dead people? 😛 And, if you are writing on other sites, I’d like to keep up with everything new you have to post.
    Could you list every one of your social sites like your twitter feed, Facebook page or linkedin profile?

    Review my webpage — mpc-install.com

  33. I actually wanted to jot down a brief word in order to appreciate
    you for all the fabulous guides you are writing on this website.
    My prolonged internet look up has finally been recognized with really good strategies to
    talk about with my classmates and friends.
    I ‘d state that that most of us site visitors actually
    are undeniably endowed to be in a magnificent site
    with many awesome individuals with very helpful pointers.

    I feel extremely lucky to have used your weblog and look forward to tons
    of more brilliant moments reading here. Thanks
    again for a lot of things.

    Here is my blog clubriders.men

  34. Hi there would you mind sharing which blog platform you’re working with?
    I’m planning to start my own blog soon but I’m having
    a hard time choosing between BlogEngine/Wordpress/B2evolution and Drupal.

    The reason I ask is because your design and style seems
    different then most blogs and I’m looking for something
    unique. P.S My apologies for getting off-topic but I had to ask!

    Here is my page — 800ws.net

  35. Good ? I should certainly pronounce, impressed with your web
    site. I had no trouble navigating through all tabs and related
    information ended up being truly simple to do to access.
    I recently found what I hoped for before you know it at
    all. Reasonably unusual. Is likely to appreciate it for those who add forums
    or something, site theme . a tones way for your customer
    to communicate. Nice task.

    my homepage :: kebe.top

  36. Hey! I understand this is kind of off-topic however I
    had to ask. Does managing a well-established blog such as yours take a massive
    amount work? I am brand new to operating a blog however I do write in my diary everyday.

    I’d like to start a blog so I will be able to share my personal experience
    and views online. Please let me know if you have
    any kind of recommendations or tips for brand new aspiring bloggers.
    Appreciate it!

    My blog aixindashi.org

  37. We wish to thank you once more for the stunning ideas you offered Jesse when preparing a post-graduate research
    plus, most importantly, pertaining to providing every
    one of the ideas within a blog post. In case we had known of your site a year ago, we might have been saved the pointless measures we were choosing.
    Thank you very much.

    Also visit my blog post … https://mpc-install.com/

  38. We wish to thank you yet again for the wonderful ideas you gave Janet when preparing a post-graduate research as well as, most importantly, for providing
    all of the ideas in one blog post. Provided we had known of your web
    page a year ago, we’d have been saved the nonessential measures we were employing.
    Thanks to you.

    Also visit my webpage: http://www.qijiang520.com

  39. Undeniably imagine that which you said. Your favourite justification seemed to be at the web the easiest thing
    to take into accout of. I say to you, I certainly get irked while people think about
    issues that they just don’t recognise about.
    You controlled to hit the nail upon the top and outlined out
    the whole thing with no need side-effects , people can take a
    signal. Will likely be back to get more. Thanks

    Here is my page: http://clubriders.men

  40. It’s a pity you don’t have a donate button! I’d without
    a doubt donate to this superb blog! I suppose for now i’ll settle for book-marking and adding your RSS feed to my
    Google account. I look forward to new updates and will talk about
    this website with my Facebook group. Talk soon!

    Here is my blog post :: kebe.top

  41. This design is spectacular! You obviously know how to keep a reader amused.
    Between your wit and your videos, I was almost moved to start my
    own blog (well, almost…HaHa!) Great job. I really enjoyed what you
    had to say, and more than that, how you presented it.
    Too cool!

    Feel free to visit my web blog :: kebe.top

  42. My wife and i got so fulfilled that Ervin could complete his survey through
    your precious recommendations he acquired from your site. It is
    now and again perplexing just to continually be making a
    gift of tips that many other people could have been selling.
    And now we do understand we now have the writer to appreciate because of
    that. Those illustrations you’ve made, the easy website menu, the relationships you
    will assist to instill — it’s got everything excellent, and it’s really assisting
    our son and us recognize that that content is satisfying,
    and that’s seriously indispensable. Thanks for the whole
    thing!

    Review my web blog — https://mpc-install.com

  43. Hey there excellent blog! Does running a blog similar to this take a massive
    amount work? I’ve virtually no knowledge of programming
    however I had been hoping to start my own blog in the near future.
    Anyhow, should you have any suggestions or tips for new blog owners please share.
    I know this is off topic however I simply wanted to ask.
    Many thanks!

    My web site :: http://clubriders.men/

  44. This is the perfect webpage for everyone who hopes to understand this topic.
    You understand a whole lot its almost hard to argue with you (not that I personally will need to?HaHa).
    You definitely put a brand new spin on a subject which has
    been written about for years. Wonderful stuff, just great!

    My web page … clubriders.men

  45. I wanted to thank you once again for this amazing web-site you have designed here.

    It really is full of ideas for those who are
    seriously interested in that subject, especially this very post.

    You’re really all actually sweet in addition to thoughtful of others as well as reading the blog
    posts is a fantastic delight to me. And thats a generous surprise!

    Dan and I are going to have fun making use of your suggestions in what we
    must do next week. Our checklist is a mile long and simply put tips are going to be put to
    good use.

    Also visit my webpage — http://clubriders.men/viewtopic.php?id=348656

  46. I don’t know whether it’s just me or if perhaps everyone else experiencing issues
    with your website. It looks like some of the written text within your posts are running off the
    screen. Can someone else please provide feedback and
    let me know if this is happening to them too?
    This may be a problem with my web browser because I’ve had this happen previously.

    Many thanks

    Also visit my homepage — http://www.lubertsi.net

  47. I must thank you for the efforts you have put in penning this website.
    I really hope to view the same high-grade blog posts by you in the future as well.
    In truth, your creative writing abilities has motivated me to get my own, personal blog now 😉

    My web-site Nuubu

  48. Hello would you mind stating which blog platform you’re using?

    I’m going to start my own blog in the near future but
    I’m having a difficult time choosing between BlogEngine/Wordpress/B2evolution and Drupal.
    The reason I ask is because your design and style seems different then most blogs and I’m looking for something
    unique. P.S Sorry for being off-topic but I had to ask!

    my homepage … Nuubu

  49. Wonderful blog! Do you have any tips and hints for aspiring writers?
    I’m hoping to start my own site soon but I’m a little lost on everything.
    Would you propose starting with a free platform like WordPress
    or go for a paid option? There are so many choices out there
    that I’m completely confused .. Any tips? Cheers!

    my website … Gentille Derma Review

  50. You’re so cool! I don’t believe I’ve read through anything like that before. So nice to discover someone with a few unique thoughts on this subject. Really.. many thanks for starting this up. This web site is one thing that is required on the web, someone with a bit of originality!

  51. I simply desired to thank you so much once more. I am not sure the things that I might have followed without the entire methods contributed by you over
    such a subject matter. It became an absolute intimidating issue
    for me, but being able to see a professional approach you resolved that made
    me to weep over fulfillment. I’m just happier for your assistance and as well ,
    wish you are aware of a powerful job that you are
    getting into instructing men and women through the use of your
    webpage. I am sure you have never got to know any of us.

    Feel free to surf to my blog post :: https://brittnycline308.webgarden.com

  52. I believe what you published made a bunch of sense.
    But, what about this? what if you were to create a killer post title?
    I mean, I don’t want to tell you how to run your blog,
    but what if you added a post title that grabbed
    people’s attention? I mean Почему гены
    рака молочной железы так же
    опасны для мужчин is a little vanilla.

    You should look at Yahoo’s home page and see how they create article headlines to get viewers interested.
    You might add a video or a pic or two to grab readers excited about everything’ve got to say.

    Just my opinion, it would make your website a little bit more interesting.

    Also visit my webpage Total Pure CBD Oil

  53. Wow, amazing blog format! How lengthy have you ever been blogging for?
    you made running a blog glance easy. The full glance of your
    website is fantastic, as neatly as the content![X-N-E-W-L-I-N-S-P-I-N-X]I simply couldn’t leave your site before suggesting that I
    really loved the usual information a person provide on your
    guests? Is going to be again frequently in order to investigate cross-check new posts.

    Feel free to visit my webpage :: Artctic Box AC

  54. hello there and thank you for your information ? I’ve definitely picked up something new
    from right here. I did however expertise several technical issues using this website, as I
    experienced to reload the web site many times previous to I could get it
    to load correctly. I had been wondering if your web hosting is OK?
    Not that I am complaining, but sluggish loading instances times will very frequently affect your placement in google and
    can damage your high-quality score if advertising and marketing
    with Adwords. Anyway I’m adding this RSS to my email and could look
    out for a lot more of your respective interesting content.
    Ensure that you update this again soon.

    Also visit my blog; Winifred

  55. My spouse and i have been quite glad that Michael could complete
    his investigations out of the ideas he discovered from your own web pages.
    It’s not at all simplistic to simply happen to be giving freely steps that many other people may have been selling.
    And we also fully grasp we need the website owner to thank because of that.

    These explanations you made, the simple web site menu,
    the friendships you can assist to create — it’s got mostly unbelievable,
    and it’s really aiding our son and the family understand this subject is pleasurable, and that is very mandatory.
    Thanks for everything!

    Have a look at my page hypnotronstudios.com

  56. hello there and thank you for your information ? I’ve certainly picked up something new from
    right here. I did however expertise several technical issues using this web site, since I
    experienced to reload the website a lot of times previous
    to I could get it to load properly. I had been wondering if your hosting is OK?
    Not that I’m complaining, but sluggish loading instances times will often affect your placement in google and could damage your high-quality score if ads
    and marketing with Adwords. Well I’m adding this RSS
    to my email and can look out for much more of your respective fascinating content.
    Make sure you update this again very soon.

    Also visit my site … Ilok Air Portable Air Conditioner

  57. Cool blog! Is your theme custom made or did you download it from somewhere?
    A theme like yours with a few simple adjustements would really make my blog stand out.
    Please let me know where you got your design. Bless
    you

    Here is my site: Floy

  58. Vielen Dank für Die Schönen Beitrag. Ich gewesen erforschen dieses Thema für irgendwann . Die Artikel und Besonderheiten Sie zeigen, ich war nicht aufmerksam. Ich wird nächste Ihre Weblog jetzt und mit etwas Glück Sie können zusätzlich Gedanken und Einsichten.

  59. A powerful share, I just given this onto a colleague who was doing somewhat evaluation on this. And he the truth is bought me breakfast as a result of I found it for him.. smile. So let me reword that: Thnx for the treat! However yeah Thnkx for spending the time to discuss this, I feel strongly about it and love studying extra on this topic. If potential, as you change into expertise, would you mind updating your weblog with extra details? It is highly helpful for me. Big thumb up for this blog put up!