В 2014 г. Всемирная организация здравоохранения заявила, что выявленная в клинических условиях устойчивость патогенных бактерий к губительному воздействию различных антибиотиков, которую считали серьезной угрозой здоровью человека в будущем, уже становится угрозой в настоящем. В результате было рекомендовано сфокусировать исследования на предотвращение наступления “пост-антибиотической” эры, когда антибиотики будут столь малоэффективны, что простые инфекции окажутся смертельно опасными.

Оказалось, что грамотная комбинация, состоящая из трех различных антибиотиков, может стать эффективным средством против выработавших устойчивость бактерий, даже в тех случаях, когда каждый антибиотик по отдельности уже не эффективен. Ключевым фактором оказался правильный подбор и научно-обоснованное сочетание разных антибиотиков. Бездумное одновременное использование двух, трех и даже большего количества антибиотиков не гарантирует гибели вызвавших заболевание бактерий, а во многих случаях, наоборот, снижает эффективность лечения.

Ученые протестировали каждое возможное сочетание шести разных антибиотиков, включая 20 разных комбинаций трех антибиотиков. В качестве подопытной бактерии была взята кишечная палочка. В результате было определено два сочетания, которые оказались значительно эффективнее ожидаемого. В них входили препараты трех различных классов химических соединений, то есть их комбинация обеспечивала максимально широкий диапазон механизмов губительного воздействия на патогенные бактерии.

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